Prof. Grimbacher is the scientific director of the Centre of Chronic Immunodeficiency at the University Hospital Freiburg. Additionally, he is a consultant for the Department of Immunology at the Royal Free Hospital, University College London, where until 2011 when he returned to Freiburg, he was the EU-Marie-Curie team leader. Previously, he was lecturer and senior scientist at the Department of Clinical Immunology, Freiburg, Germany. He completed his postdoc at the NIH, National Human Genome Institute. Amongst his numerous awards and honours, he was granted the Emmy-Noether Fellowship of the Deutsche Forschungsgemeinschaft (DFG), the Marie-Curie Excellence Grant of the European Commission, the Georges Köhler Award of the German Immunology Society (DGfI), the Richard Farr Memorial Lectureship at AAAAI, and the Rudolf-Schoen Prize from the Medizinische Hochschule Hannover and most recently the Thieme prize from the Leopoldina, the German Research Society. In 2004 Prof. Grimbacher has set up the ESID registry, an internet based patient and research database for over 200 different primary immunodeficiencies which was supported and sponsored by the European Commission under the 6th Framework Programme. From 2006 to 2010, Prof. Grimbacher was the secretary of the European Society for Immunodeficiencies. He held an associate editor position at the Journal of Clinical Immunology in 2013. Prof. Grimbacher was critically involved in the identification of the first three genetic causes of common variable immunodeficiency, the most prevalent primary human immunodeficiency; three causes of severe congenital neutropenia including the Kostmann syndrome; and more recently the causes of the hyper IgE syndromes, chronic mucocutaneous candidiasis, and the first monogenetic cause for inflammatory bowel disease. He currently has six publications in the prestigious New England Journal of Medicine and was critically involved in the identification of more than 12 monogenetic causes for primary immunodeficiencies.
Research of his current 17-members team centers around T cell co-stimulation (human ICOS- and CTLA-4 deficiency), the stress response of B cells and plasma cells, autophagy in the immune system (and the role of LRBA in this process), IgE regulation, and the host defence against candida.