Professor Rudi W. Hendriks, PhD is head of the experimental research laboratory of the Department of Pulmonary Medicine of the Erasmus MC Rotterdam, the Netherlands. He studied biology at the University of Utrecht and did his PhD studies on the genetics of human X-linked immunodeficiency diseases in the Department of Immunohaematology at the Leiden University Medical Center (Prof. J.J. van Rood; Dr. R.K.B. Schuurman). After a post-doctoral training in the Genetics Laboratory of the University of Oxford, UK, in 1993 he started his own line of research within the lab of Prof. Frank Grosveld at the Department of Cell Biology and Genetics of the Erasmus MC Rotterdam, the Netherlands. In 1999 he moved his group to the Department of Immunology at the Erasmus MC. His research focuses on the molecular biology of lymphocytes. The largest effort has gone into the generation of transgenic and knock-out mice to understand the role of signaling molecules and transcription factors in the regulation of lymphocyte differentiation and function. With this background in lymphocyte biology, he moved to the Department of Pulmonary Medicine of the Erasmus MC in 2007. The research program has gradually developed towards a more integrated program studying the role of lymphocytes in the in vivo context of innate and adaptive immunity, particularly in the lung. A main line of research is the differentiation program of lymphocytes in health and disease, in particular (1) the regulation of differentiation and function of T helper subsets and group 2 innate lymphoid cells in the context of type II immunity, and (2) the role of aberrant B and T cell activation in autoimmunity and interstitial lung disease.